Bone markers and osteoporosis

Bone markers and osteoporosis

BY:

SH.ALAMDARI, MD

ENDOCRINOLOGIST

SBMU, RIES

Objectives:

1. Bone formation markers
2. Bone resorption markers
3. Potential usage
4. Which marker? Which cut off to use? LSC: Least Significant Change
5. Timing of sampling
6. Problems in usage of bone markers
7. Recommendations

-Bone markers are indices of bone metabolism

Bone turnover markers:

• BONE FORMATION MARKERS
  • OC: Osteocalcin;
  • BALP: Bone-specific alkaline phosphatase;
  • P1NP: N-terminal propeptide of type 1 procollagen;
  • P1CP: C-terminal propeptide of type 1 procollagen;

Bone turnover markers:

• BONE RESORPTION MARKERS
  • NTX: cross-linked N-telopeptide of type 1 collagen;
  • CTX: cross-linked C- telopeptide of type 1 collagen;
  • D-PYR: Free deoxypyridinoline;
  • PYD: Free pyridinoline;
  • HYP: Hydroxyproline;
  • TRACP5b: isoform 5b of tartrate resistant acid phosphatase.